जेनेटिक्स और जीन थेरेपी जर्नल

Interface Between Bioinformatics and Virology

Martin Hölzer

In the last years, we have witnessed both the emergence of new viral diseases (e.g. MERS, SARS) and therefore the re-emergence of known diseases in new geographical areas (e.g. Zika, Dengue and Chikungunya). Virologists have traditionally concentrated on studying viruses that cause disease in humans, animals or plants. However, there has been estimated around 1031 viruses within the biosphere and only a minuscule fraction has been identified, yet. On the other hand, the power of new genome sequencing technologies, associated with new tools to handle “big data”, provide unprecedented opportunities to address fundamental questions in virology. We would like to emphasize that many of the common questions raised in virology require specific bioinformatics support and for the need to bring together the expertise of bioinformaticians and virologists. For this mission, the ecu Virus Bioinformatics Center (EVBC) was founded on 8th March 2017 in Jena, Germany. The EVBC has about 100 founding members from over 50 research institutions distributed across 13 European countries. I will present first attempts to tackle with virus-specific programs open questions in (co-)phylogeny, high-throughput sequencing data analysis, virus detection, virus-host interaction and host barriers.