आणविक क्लोनिंग और आनुवंशिक पुनर्संयोजन

The Arrival of ‘knockout’ Rats

Muhammad Farooq and Gabrielle M. Hawksworth

The Arrival of ‘knockout’ Rats

‘Knockout’ technology is a valuable tool in identifying causative genes resulting in disease states. Over the last three decades, it has only been possible to use the mouse for this purpose, owing to the non-responsiveness of rat embryonic stem cells (ESCs) to the culture conditions that were successfully used to construct ‘knockout’ mice. But during the last few years, this situation has changed and successful novel approaches for the construction of ‘knockout’ rats have brought the rat back centre stage.

अस्वीकृति: इस सारांश का अनुवाद कृत्रिम बुद्धिमत्ता उपकरणों का उपयोग करके किया गया है और इसे अभी तक समीक्षा या सत्यापित नहीं किया गया है।

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