Jinbo Liu, Jie Chen and Hongyu Wang*
The novel Coronavirus Disease (COVID-19) outbreak, caused by SARS-CoV-2, represents the greatest medical challenge in decades. We provide a comprehensive review of the clinical course of COVID-19, its comorbidities, and mechanistic considerations for future therapies. While COVID-19 primarily affects the lungs, causing interstitial pneumonitis and severe Acute Respiratory Distress Syndrome (ARDS), it also affects multiple organs, particularly the cardiovascular system.
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