Daniele Roberto Giacobbe
Typhoid fever acute and unspecified infection of the reticuloendothelial system caused by Salmonella typhi, and causes substantial hepatic complications and biochemical changes. Currently, the diagnostic test is isolation of bacteria from blood, stool, and rarely urine, but serologic tests are still commonly used. There is still a need to introduce rapid and reliable test for typhoid fever. The main purpose of this study was to determine the hematological variations in adult typhoid patients as compared to healthy control. A total of 50 patients and 50 healthy individuals were enrolled in this research, and variations in hematological factors were studied. Hematological parameters were found deranged in typhoid fever including hemoglobin (low, 10.97 ± 0.88), hematocrit (low, 37.72 ± 1.40), ESR (high 45.08 ± 13.42), platelet count (high 588840 ± 97185), WBCs count (high 38267 ± 22279), neutrophil percentage (high, 73.56 ± 9.96), lymphocyte percentage (low, 21.24 ± 10.08), and NLCR (high, 5.14 ± 4.00) as compared to healthy control group. This differentiating pattern is easy to obtain by minimal invasive procedure and can be used for typhoid infection diagnosis.
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